About us
Introduction

The CloudHealth Genomics is a comprehensive genomics-based precision medicine solutions provider focused on bringing the best practices in diagnostics through innovation and high-throughput genomics to the global healthcare ecosystem. As one of China's leading genomics solution providers, we are leveraging over 40 years of combined pharma, clinical and translational science experience to advance precision medicine.

CloudHealth Genomics prides itself with a certified clinical lab and high-throughput genomics platform to generate genomic data, to understand, diagnose and provide solutions to treat disease with an emphasis of using “big data” to develop preventive medicine metrics and guidance to develop precision medicines for a healthier society with the goal of reducing disease risks and an improved quality of life.



CloudHealth Genomics, Ltd. is a comprehensive genomics-based precision medicine solutions provider focused on bringing the best practices in diagnostics through innovation (liquid biopsy) and high-throughput (HighSeq X 10) genomics to the global healthcare ecosystem. CloudHealth Genomics is part of a larger CloudHealth Medical Group ecosystem, comprising of CloudHealth Life Center, CloudHealth High-End Clinic Center, CloudHealth Big Data Center, CloudHealth Genomics Research Institute, Academician Experts Workstation. CloudHealth Club of Medical Doctors, founded in 2014 and headquartered in Shanghai, China with international branches in US and Europe.

 

CloudHealth Genomics prides itself with a high-throughput genomics sequencing platform and a certified clinical genetic test lab to generate genomic data, to understand, diagnose and provide solutions to treat disease with an emphasis of using “big data” to develop preventive medicine metrics and guidance to develop precision medicines for a healthier society. In addition, through our integrated health management infrastructure, a “myCloudReportTM” is generated and reviewed by our local and international team of genetic counselors. The goal of CloudHealth Genomics is reducing disease risks and an improved quality of life for both our healthy and those at risk for disease, first in China, and then globally.   

 

Milestone
2017
2016
2015
2014
2017.01

CloudHealth released the first liquid genome sequencing testing product targeted on healthy people worldwide.

2017.04

Nanjing CloudHealth performed the first batch of NovaSeq high-throughput sequencing platform globally.

2017.05

CloudHealth had struck strategic cooperation intention with Yangzi Group, Harvard-MIT and Broad research institution.

2017.06

CloudHealth launched precision medical cooperation plan of “One Belt & One Road” in Mongolia.

2016.01

CloudHealth Medical Group established

2016.04

National Development and Reform Commission certifies CloudHealth Genomics "genetic testing center"

2016.07

CloudHealth partners with Gongli Hospital for precision health management insurance program

2016.07

CloundHealth Genome & Health Research Center established

2016.07

CloudHealth Longevity & Health Research Center established

2016.07

CloudHealth participates "Standardized Technology System for Big Data Processing and Utilization of Precision Medicine" led by Beijing Genomics Institute of Chinese Academy of Sciences

2016.09

CloundHealth Genome & Health Research Center established

2016.10

Recognition by the "Health Education Association Health Communication Branch" of Shanghai as China’s comprehensive precision medicine platform

2016.10

Shanghai Economic Information Commission funds CloudHealth for Big Data Program for Chinese Population Health Program

2016.11

Shanghai Zhangjiang National Innovation Demonstration Zone funds CloudHealth for “Bio-database for whole genome product trial project"

2016.11

CloudHealth valued at over 1 Billion RMB

2016.11

CloudHealth recieves "Outstanding Academician Expert Workstation" award

2016.11

CloudHealth completes Cooperation Agreement with Shanghai International Medical Center

2015.01

Cooperation with CloudHealth Genomics and Illumina

2015.02

CloudHealth Clinic established

2015.04

Funding for CloudHealth Molecular Medical Laboratory

2015.05

Grand opening of CloudHealth Genomics Ltd. /Launch Molecular Medical Laboratory /Funding for Academician Workstation

2015.07

CloudHealth X10 sequencing platform launch

2015.10

Approval by Shanghai Economic Information Commission for ultra-high-throughput sequencing platform projects

2015.12

CloudHealth Genomics enters International Precision Medicine Cooperation Center in China Free Trade Zone

2015.12

Completed the acquisition of 13 software copyrights

2014.02

CloudHealth established in Shanghai, China

2014.09

Seed Funding for CloudHealth Genomics

2014.10

Seed Funding for CloudHealth HiSeq X Ten Laboratory

Publications
Liquid biopsy(6)

Malaria extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes. Mantel, PY, Hjelmqvist, D, Nilsson, S, Ravel, D, Ribeiro, M, Grüring, C, Ma, S, Padmanabhan, P, Trachtenberg, AJ, Ankarklev, J, Brancucci, N, Huttenhower, C, Duraisingh, MT, Ghiran, I, Kuo, WP, Martinelli, R, Marti, M., Nature Communications, 2016 a. 

Emerging technologies in extracellular vesicle-based molecular diagnostics. Jia S, Zocco D, Samuels ML, Chou MF, Chammas R, Skog J, Zarovni N, Momen-Heravi F, Kuo WP. Expert Rev Mol Diagn. 2014;14(3):307-21.

Short Course in Extracellular Vesicles – The Transition from Tissue to Liquid Biopsies. Lötvall J, Skog J, Vlassov AV, Sacido AA, Rohde E, Gere J, Kuo WP. Journal of Circulating Biomarkers. 2014, 3 (8), 1-5.

Detection Of Human c-Myc and EGFR Amplifications in Circulating Extracellular Vesicles in Mouse Tumour Models. Balaj L, Momen-Heravi F, Chen W, Sivaraman S, Zhang X, Ludwig N, Meese E, Wurdinger T, Noske D, Charest A, Hochberg FH, Vandertop P, Skog J, Kuo WP. Journal of Circulating Biomarkers. 2014, 3 (6), 1-7. 

Extracellular vesicles as shuttles of tumor biomarkers and anti-tumor drugs. Zocco D, Ferruzzi P, Cappello F, Kuo WP, Fais S. Front Oncol. 2014;4:267.

Current methods for the isolation of extracellular vesicles. Momen-Heravi F, Balaj L, Alian S, Mantel PY, Halleck AE, Trachtenberg AJ, Soria CE, Oquin S, Bonebreak CM, Saracoglu E, Skog J, Kuo WP. Biol Chem. 2013, 394(10):1253-62.

Alternative methods for characterization of extracellular vesicles. Momen-Heravi F, Balaj L, Alian S, Tigges J, Toxavidis V, Ericsson M, Distel RJ, Ivanov AR, Skog J, Kuo WP. Front Physiol. 2012;3:354. Impact of biofluid viscosity on size and sedimentation efficiency of the isolated microvesicles. Momen-Heravi F, Balaj L, Alian S, Trachtenberg AJ, Hochberg FH, Skog J, Kuo WP. Front Physiol. 2012;3:162.




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Next-Generation Sequencing(2)

Genomic landscape and genetic het¬erogeneity in gastric adenocarcinoma revealed by whole-genome sequencing. Swee Seong Wong, Kyoung-Mee Kim, Jason C. Ting, Kun Yu, Jake Fu Shawn Liu, Razvan Cristescu, Michael Nebozhyn, Lara Gong, Yong Gang Yue , Jian Wang , Chen Ronghua, Andrey Loboda, James Hardwick, Xiaoqiao Liu, Hongyue Dai, Jin JG, Xiang S. Ye , So Young Kang, In Gu Do, Joon Oh Park, Tae Sung Sohn, Christoph Reinhard , Jeeyun Lee, Sung Kim & Amit Aggarwal. Nature Communications, 2014. 5.

The draft genome of the large yellow croaker reveals well-developed innate immunity. Changwen Wu, Di Zhang, Mengyuan Kan, Zhengmin Lv, Aiyi Zhu, Yongquan Su, Daizhan Zhou, Jianshe Zhang , Zhou Zhang, Meiying Xu , Lihua Jiang, Baoying Guo, Ting Wang, Changfeng Chi , Yong Mao, Jiajian Zhou , Xinxiu Yu, Hailing Wang, Xiaoling Weng, Jin JG, Junyi Ye, Lin He & Yun Liu., Nature Communications, 2014. 5.

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Bioinformatics(7)

AnyExpress: integrated toolkit for analysis of cross-platform gene expression data using a fast interval matching algorithm. Kim J, Patel K, Jung H, Kuo WP, Ohno-Machado L. BMC Bioinformatics. 2011;12:75.

Error margin analysis for feature gene extraction. Chow CK, Zhu HL, Lacy J, Kuo WP. BMC Bioinformatics. 2010; 11: 241.

Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates. Liu F, Jenssen TK, Trimarchi J, Punzo C, Cepko CL, Ohno-Machado L, Hovig E, Kuo WP. BMC Genomics. 2007;8:153.

Automatic correspondence of tags and genes (ACTG): a tool for the analysis of SAGE, MPSS and SBS data. Galante PA, Trimarchi J, Cepko CL, de Souza SJ, Ohno-Machado L, Kuo WP. Bioinformatics. 2007;23(7):903-5.

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. MAQC Consortium. Nat Biotechnol. 2006;24(9):1151-61. (Kuo WP is one of the key contributors)

A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF 3rd, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK. Nat Biotechnol. 2006;24(7):832-40.

Analysis of matched mRNA measurements from two different microarray technologies. Kuo WP, Jenssen TK, Butte AJ, Ohno-Machado L, Kohane IS. Bioinformatics. 2002;18(3):405-12.


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Biomarker development(12)

Endothelial and circulating placental C19MC microRNAs distinguish propranolol-responsive infantile hemangioma from other vascular anomalies. Strub GM, Kirsh AL, Whipple MW, Kuo WP, Keller RB, Kapur RP, Perkins JA, Majesky MW. JCI Insight. 2016 Sep 8;1(14):e88856. doi: 10.1172/jci.insight.88856.

Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma. Hua Y, Choi PW, Trachtenberg AJ, Ng AC, Kuo WP, Ng SK, Dinulescu DM, Matzuk MM, Berkowitz RS, Ng SW., Oncotarget. 2016 Sep 1. doi: 10.18632/oncotarget.11808.

Molecular Changes in Endometriosis-Associated Ovarian Clear Cell Carcinoma. Worley, MJ, Liu, S, Hua, Y, Kwok, JS, Samuel, A, Hou, L, Shoni, M, Lu, S, Sandberg, EM, Keryan, A, Wu, D, Ng, SK, Kuo WP, Parra-Herran, CE, Tsui, SK, Welch, W, Crum, C, Berkowitz, RS and Ng, SW., Eur J Cancer. 2015 Jun 6. pii: S0959-8049(15)00442-6. doi: 10.1016/j.ejca.2015.05.011.

NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Tullius SG, Biefer HR, Li S, Trachtenberg AJ, Edtinger K, Quante M, Krenzien F, Uehara H, Yang X, Kissick HT, Kuo WP, Ghiran I, de la Fuente MA, Arredouani MS, Camacho V, Tigges JC, Toxavidis V, El Fatimy R, Smith BD, Vasudevan A, ElKhal A., Nat Commun. 2014 Oct 7;5:5101. doi: 10.1038/ncomms6101.

Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer. Momen-Heravi F, Trachtenberg AJ, Kuo WP, Cheng YS. J Dent Res. 2014 Apr 9;93(7 suppl):86S-93S.

miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway. Zhao JJ, Lin J, Zhu D, Wang X, Brooks D, Chen M, Chu ZB, Takada K, Ciccarelli B, Admin S, Tao J, Tai YT, Treon S, Pinkus G,Kuo WP, Hideshima T, Bouxsein M, Munshi N, Anderson K, Carrasco R. Cancer Res. 2014 Mar 15;74(6):1801-13. doi: 10.1158/0008-5472.CAN-13-3311-T. Epub 2014 Mar 5.

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.Wang G, Lunardi A, Zhang J, Chen Z, Ala U, Webster KA, Tay Y, Gonzalez-Billalabeitia E, Egia A, Shaffer DR, Carver B, Liu XS, Taulli R,Kuo WP, Nardella C, Signoretti S, Cordon-Cardo C, Gerald WL, Pandolfi PP. Nat Genet. 2013 Jun 2. doi: 10.1038/ng.2654.

A microRNA panel to discriminate carcinomas from high-grade intraepithelial neoplasms in colonoscopy biopsy tissue. Wang S, Wang L, Bayaxi N, Li J, Verhaegh W, Janevski A, Varadan V, Ren Y, Merkle D, Meng X, Gao X, Wang H, Ren J, Kuo WP, Dimitrova N, Wu Y, Zhu H. Gut. 2013;62(2):280-9.

Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. Thompson AJ, Clark PJ, Singh A, Ge D, Fellay J, Zhu M, Zhu Q, Urban TJ, Patel K, Tillmann HL, Naggie S, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, King JW, Kwo PY, Shianna KV, Noviello S, Pedicone LD, Brass CA, Albrecht JK, Sulkowski MS, Goldstein DB, McHutchison JG, Muir AJ, Journal of Hepatology, 2012. 56(2): p. 313-319.

Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumor growth in mice. Xiang W, Ke Z, Zhang Y, Cheng GH, Irwan ID, Sulochana KN, Potturi P, Wang Z, Yang H, Wang J, Zhuo L, Kini RM, Ge R. J Cell Mol Med, 2009, Oct 29.

The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor. Sharghi-Namini S, Fan H, Sulochana KN, Potturi P, Xiang W, Chong YS,Wang Z, Yang H, Ge R, Biochem Biophys Res Commun. 2008. 371(2):215-9.

Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications. Hasina R, Whipple ME, Martin LE, Kuo WP, Ohno-Machado L, Lingen MW. (2008) Lab Invest. Apr;88(4):342-53. Epub 2008 Feb 18.


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